1 edition of Variation in susceptibility of guinea-pigs to diphtheria toxin found in the catalog.
|Statement||by H.J. S©ơdmersen and A.T. Glenny|
|Contributions||Glenny, Alexander Thomas, Royal College of Surgeons of England|
|The Physical Object|
|Pagination||p. 400-408 ;|
|Number of Pages||408|
A soluble antigen obtained from ether extracted yolk-sac suspension was demonstrated independently and at approximately the same time by two of the research laboratories (Army Medical School and National Institute of Health). A vaccine containing a greater concentration of rickettsiae and soluble antigen was prepared and tested in man. The "Arthus type" variation classically causes a reaction only at the injection site, but the result is an acute necrotizing vasculitis and localized necrosis (death) of the tissues. The reaction starts 2 -- 8 hours after a tetanus toxiod injection and occurs if the person has very high serum antitoxin antibodies due to overly frequent injections.
Anderson P. Antibody responses to H. influenzae type b and diphtheria toxin induced by conjugates of oligosaccharides of the type b capsule with the nontoxic protein CRM Infection and Immunity ; Wilson S. Sensitization of guinea-pigs to measles vaccines. Clinical Experimental Immunology Arakawa Y. Amaki S. The biological potency of these compounds is high, but the actual toxicity is low. The 50% lethal dose in female rats is greater t mg/kg; in female guinea pigs it is 5, mg/kg, while as little as one μg/kg may create a detectable uterogenic response in female swine. Thus, mycoestrogen is a more appropriate rubric than mycotoxin.
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Variations and quotations
Laboratory animals vary considerably in their reaction to the diphtheria bacillus according to the susceptibility of their tissues to the toxin. Rats and mice possess a high degree of resistance ; this appears to be an example of natural species immunity, as.
Publisher Summary. The subject of bacterial destruction is complex, because of a large number of variable factors involved in the process. For examination of any disinfection process, the following points are considered: (a) the nature of the organism Variation in susceptibility of guinea-pigs to diphtheria toxin book are more resistant than vegetative organisms, among which great individual variation in susceptibility to various.
Corynebacterium diphtheriae is the classical etiological agent of diphtheria and the type strain of the genus Corynebacterium. While diphtheria of the respiratory tract became rare with the Author: Andreas Burkovski.
Tetrodotoxin (TTX) is a potent name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish; several of these species carry the gh tetrodotoxin was discovered in these fish and found in several other animals (e.g., in blue-ringed octopuses, rough-skinned newts, and moon snails), it is actually produced by CAS Number: Diphtheria was a major cause of death among children until the beginning of the nineteenth century.
The introduction in the s of formaldehyde-detoxified diphtheria toxin for mass immunization. In the early literature, vitamin C deficiency was associated with pneumonia. After its identification, a number of studies investigated the effects of vitamin C on diverse infections.
A total of animal studies indicated that vitamin C may alleviate or prevent infections caused by bacteria, viruses, and protozoa. The most extensively studied human infection is the common by: SMITH, THEOBALD (, New York, 31 July ; d.
New York, N.Y., 10 December ). microbiology, comparative pathology. The scope and thoroughness of Smith’s researches in bacteriology, immunology, and parasitology produced many discoveries of theoretical import and immediate utility to public health and veterinary was the most distinguished early.
Recently, our ability to manipulate the mouse genome has become increasingly refined with developments such as tissue-specific methods of knocking out genes such as the Cre-Lox system,4 methods of turning on or off gene transcription in vivo using tetracycline- or tamoxifen-induced systems,5 and methods of identifying or removing entire cell.
SECTION 1 THE GERM THEORY OF DIPHTHERIA. The attempt in recent years to prevent diphtheria by the injection of toxin-antitoxin and similar products, as well as the routine treatment of diphtheria, when it occurs, by antitoxic serum, is based upon the primary fallacy that diphtheria is caused by a "germ"—the Klebs-Loeffler bacillus.
This banner text can have markup. web; books; video; audio; software; images; Toggle navigation. Inthe unusual resistance of the mouse to diphtheria infections was attributed to its ability to synthesize rapidly its own ascorbic acid, while the guinea pig's ready susceptibility to this disease (like man's) was attributed to its inability to replenish its store of ascorbic acid.
Several methods of testing the antigenic power of formol-toxoid prepared for human immunization are compared. The method recommended is briefly as follows. A series of guineapigs (up to 25 in number) are injected with one dose of toxoid (e.g., 1 cc.) and days later the immunity of the animals is tested by injecting a living culture of diphtheria bacilli containing M.L.D.
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The author has observed that young albino rats up to 30 days of age suffer less intensive infection with T. cruzi during the summer months than during the fall, winter and early spring seasons. Reference is made to similar observations by other investigators upon seasonal variations in the susceptibility of guineapigs and mice to diphtheria toxin, encephalitis virus and rickettsia of endemic Cited by: 2.
The futility of the experiments is apparent and it is certain that had a small proportion of the time and money thus wasted been devoted to investigating the effects of habits of life (and particularly diet) in causing cancer in human beings, conclusions of practical value would have been reached.
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It also Provides insights into global control and the switch between distinct infectious states (acute versus chronic). On 27 Januaryhowever, within twelve hours after twenty-one children in Bundaberg, in Queensland, had received injections of a diphtheria toxin-antitoxin mixture (then the accepted method of immunization against diphtheria), eighteen of them had become.
Visit to get more information about this book, to buy it in print, or to download it as a free PDF. In vivo tests: Subcutaneous test: The growth from an overnight culture on Loeffler's slope is emulsified in ml broth and ml of the emulsion injected subcutaneously into two guinea pigs, one of which has been protected with units of the diphtheria antitoxin hours previously.
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A major focus of the book is the molecular elucidation of bacterial properties which enable Legionella to thrive in the aquatic environment and to infect the human host.Mass immunization efforts continued, and "bythe diphtheria cases were more than tripled to 46," 79; Diphtheria increased by 55 percent in Hungary and tripled in Geneva, Switzerland after the introduction of compulsory immunization laws.
The first successful use of formaldehyde treatment was in the field of toxin inactivation. Here, Glenny and Hopkins accidentally discovered (Brown ) that residual traces of formalin—used for cleaning—rendered batches of diphtheria toxin non-toxic in guinea pigs (Glenny and Hopkins ).Cited by: 7.